NR+ 300 NAD+ Booster with Nicotinamide Riboside & Resveratrol

By age 50, your NAD+ levels have dropped by roughly half of what they were at 20 — and that decline is not a side effect of aging. It is one of its primary drivers.

 NAD+ (Nicotinamide Adenine Dinucleotide) is the coenzyme at the center of cellular energy production, DNA repair, mitochondrial function, and the activation of sirtuins — the longevity proteins that regulate how your cells age. When NAD+ falls, mitochondria become less efficient, DNA damage accumulates faster than it can be repaired, cellular senescence accelerates, and the downstream effects show up as fatigue, brain fog, metabolic slowdown, reduced physical performance, and accelerated aging across every system in the body. NR+ 300 addresses this at the source — 300mg of Nicotinamide Riboside (NR), the most clinically studied NAD+ precursor, combined with 50mg of trans-resveratrol (98% pure) to activate the sirtuin pathways that NAD+ powers. A dual-action longevity formula that works at the cellular level. 60 vegan capsules — 30 to 60-day supply.

Is This You?

Chronic fatigue or low energy despite adequate sleep · brain fog, poor concentration, or cognitive decline · reduced physical performance, endurance, or muscle recovery · slower metabolism or unexplained weight changes · poor sleep quality or slow recovery · adults 40+ experiencing age-related decline · longevity and healthspan optimization · biohackers and performance-focused individuals · metabolic health and insulin sensitivity support · cardiovascular health and vascular aging · proactive cellular health before symptoms develop

What You’ll Experience

NAD+ Restoration & Cellular Energy: Nicotinamide Riboside (NR) is a direct precursor to NAD+ — it enters cells and is converted to NAD+ through a well-characterized enzymatic pathway. At 300mg — the dose used in published human clinical trials — NR has been shown to increase NAD+ levels by 40–60% within weeks of consistent use. Restored NAD+ levels directly enhance mitochondrial function and ATP synthesis, the process by which your cells convert nutrients into usable energy. The result is not a stimulant effect but a genuine improvement in cellular energy capacity — more efficient mitochondria producing more ATP, translating to sustained energy, reduced fatigue, and improved physical and mental performance.

Sirtuin Activation & Longevity Pathways: Sirtuins (SIRT1–7) are a family of proteins often called “longevity genes” — they regulate DNA repair, cellular stress responses, inflammation, metabolic function, and the rate of cellular aging. Sirtuins require NAD+ as a cofactor to function — when NAD+ declines, sirtuin activity declines with it. NR restores the NAD+ that sirtuins need to operate. Trans-resveratrol (50mg, 98% pure) directly activates SIRT1 — the primary longevity sirtuin — amplifying the effect of restored NAD+ levels. This NR + resveratrol combination addresses the longevity pathway from two angles simultaneously: NR provides the fuel, resveratrol activates the engine.

DNA Repair & Cellular Senescence: One of the most critical functions of NAD+ is supporting PARP enzymes — the proteins responsible for detecting and repairing DNA damage. As NAD+ declines with age, PARP activity slows, DNA damage accumulates faster than it can be repaired, and cellular senescence (the accumulation of dysfunctional “zombie cells” that drive inflammation and tissue aging) accelerates. Restoring NAD+ through NR supplementation supports PARP-mediated DNA repair, reduces the rate of cellular senescence, and supports genomic stability — addressing aging at its most fundamental biological level.

Cognitive Function & Brain Health: The brain is one of the most metabolically demanding organs in the body and one of the most sensitive to NAD+ decline. Neuronal NAD+ supports mitochondrial energy production in brain cells, protects against neurodegeneration, supports neuroplasticity, and maintains the myelin sheaths that enable fast neural communication. Resveratrol crosses the blood-brain barrier — providing direct neuroprotection, reducing neuroinflammation, and supporting cerebral blood flow. Together, NR and resveratrol support cognitive clarity, memory, focus, and healthy brain aging. Most people notice meaningful improvements in mental clarity and cognitive performance within 2–4 weeks.

Metabolic Health & Insulin Sensitivity: NAD+ is a central regulator of metabolic function — it is required for the enzymatic reactions that govern glucose metabolism, fat oxidation, and insulin signaling. Declining NAD+ contributes directly to reduced metabolic flexibility, impaired insulin sensitivity, and the metabolic dysfunction associated with aging. NR supplementation supports healthy glucose metabolism, improves insulin sensitivity, enhances fat burning, and supports healthy liver function. Resveratrol complements these effects through its own insulin-sensitizing and metabolic-regulating properties — mimicking aspects of caloric restriction at the cellular level.

Cardiovascular Health & Vascular Aging: NAD+ supports endothelial function — the health of the cells lining blood vessels — and vascular elasticity, both of which decline with age and contribute to cardiovascular risk. NR supports healthy blood vessel function, circulation, and cardiovascular resilience. Resveratrol provides additional cardiovascular support through its antioxidant protection of vascular tissue, support for healthy blood pressure within normal range, and reduction of arterial stiffness. The combination supports comprehensive cardiovascular health from both the cellular energy and antioxidant protection angles.

Results Timeline

• Weeks 1–2: Initial NAD+ boost begins; improved energy and reduced fatigue; better mental clarity and focus; enhanced physical stamina
• Weeks 2–4: Noticeable improvements in energy, endurance, and vitality; better sleep quality and recovery; enhanced cognitive function; reduced brain fog; improved exercise performance
• Weeks 4–8: Significant improvements in overall wellness; optimal NAD+ levels approached; enhanced metabolic function; better cardiovascular health markers; improved skin appearance; enhanced muscle strength and recovery
• Weeks 8–12: Maximum longevity benefits achieved; sustained high energy and vitality; optimal cognitive performance; enhanced physical performance and endurance; improved metabolic health; better stress resilience
• 3+ Months: Continued comprehensive cellular anti-aging support; optimal NAD+ levels maintained; sustained energy, cognitive function, and physical performance; consistent daily use recommended for ongoing cellular rejuvenation

What’s Inside

Serving size: 1–2 capsules daily | 60 vegan capsules per bottle
60-day supply at 1 capsule daily · 30-day supply at 2 capsules daily

Nicotinamide Riboside (NR) — 300mg per capsule
The most clinically studied NAD+ precursor with a well-established human safety profile. Directly converts to NAD+ in cells through a highly efficient enzymatic pathway. Clinical trials demonstrate 40–60% increases in NAD+ levels at this dose. Supports mitochondrial function, ATP synthesis, DNA repair via PARP enzymes, sirtuin activation, and cellular senescence reduction.

Trans-Resveratrol — 50mg per capsule (98% pure)
The most bioactive form of resveratrol — standardized to 98% purity for consistent potency. Derived from Japanese knotweed. Directly activates SIRT1 longevity pathway, crosses the blood-brain barrier for neuroprotection, provides powerful polyphenol antioxidant protection, and works synergistically with NR to amplify NAD+-dependent sirtuin activity.

Why NR over NMN? Both effectively raise NAD+ levels. NR has more published human clinical trials, a longer established safety record, and is more cost-effective. NMN enters the NAD+ pathway one step closer to NAD+ but at a significantly higher cost. For most people, NR at 300mg provides clinically meaningful NAD+ restoration.

Other ingredients: Vegetable cellulose capsule, microcrystalline cellulose, magnesium stearate (vegetable)

How to Take

Standard dose (1 capsule daily): Take 1 capsule in the morning with breakfast — provides 300mg NR, the dose used in most clinical studies. Ideal for maintenance and longevity support.

Enhanced dose (2 capsules daily): Take 2 capsules in the morning with breakfast for maximum NAD+ boosting and accelerated cellular support — provides 600mg NR daily.

Take with a meal containing healthy fats (avocado, nuts, olive oil) to enhance resveratrol absorption — resveratrol is fat-soluble. Take in the morning; NR may increase energy and alertness and can interfere with sleep if taken in the evening.

Pro tips: Start with 1 capsule daily for the first week before increasing to 2. Pair with healthy fats for optimal resveratrol absorption. Exercise regularly — physical activity synergizes with NAD+ to enhance mitochondrial benefits. Limit alcohol and processed foods, which actively deplete NAD+. For personalized dosing guidance or to discuss stacking with other longevity supplements, contact us at 412-347-2478 to speak with a practitioner.

Quality & Safety

Full-panel third-party tested (heavy metals, pesticides, microbials) · 300mg pharmaceutical-grade NR · Trans-resveratrol 98% pure · GMP-certified USA manufacturing · Vegan cellulose capsules · Non-GMO · Allergen-free (gluten, dairy, soy, eggs, fish, shellfish, tree nuts, peanuts-free) · No artificial colors, flavors, or preservatives.

• Blood thinners (warfarin): Resveratrol may affect clotting — consult your healthcare provider
• Diabetes medications: NR and resveratrol may affect blood sugar levels — monitor and consult your healthcare provider
• Blood pressure medications: May have additive effects — consult your healthcare provider
• Immunosuppressants: May affect immune function — consult your healthcare provider
• Active cancer: Consult your oncologist before use — NR and resveratrol affect cellular metabolism
• Surgery: Discontinue at least 2 weeks before scheduled surgery
• Pregnancy & nursing: Not recommended due to limited safety data — consult your healthcare provider
• Children under 18: Not intended for use without healthcare provider guidance
• Digestive sensitivity: Take with food to minimize any potential stomach sensitivity — NR is generally very well-tolerated

Frequently Asked Questions

What is NR (Nicotinamide Riboside) and how does it work? NR is a form of Vitamin B3 and a direct precursor to NAD+ — the coenzyme your cells rely on for energy production, DNA repair, and healthy aging. NAD+ levels decline by up to 50% by age 50, and NR is one of the most clinically studied ways to restore them. At 300mg, NR has been shown to increase NAD+ levels by 40–60% in human clinical trials.

What is the difference between NR and NMN? Both NR and NMN raise NAD+ levels through slightly different pathways — NR converts to NMN before becoming NAD+, while NMN enters one step closer. NR has more published human clinical trials and a longer established safety record. NMN is more expensive. For most people, NR at 300mg provides clinically meaningful NAD+ restoration at better value.

Why combine NR with resveratrol? NR increases NAD+ levels. Resveratrol directly activates SIRT1 — the longevity sirtuin that requires NAD+ to function. Together they address the longevity pathway from two angles: NR provides the fuel, resveratrol activates the engine. The combination is more comprehensive than either ingredient alone.

How long before I notice results? Many people notice improved energy and mental clarity within 1–2 weeks. More significant improvements in cognitive function, physical performance, and metabolic health typically develop over 4–8 weeks. Deeper cellular repair and longevity benefits accumulate over months of consistent use — NAD+ restoration is a long-term investment in cellular health.

Can I take NR+ 300 alongside NMN? Some longevity enthusiasts stack both NR and NMN for comprehensive NAD+ support. We recommend speaking with one of our practitioners at 412-347-2478 before combining NAD+ precursors to ensure the protocol is right for your individual needs.

Is NR safe for long-term daily use? Yes. NR has been studied in multiple human clinical trials with an excellent safety profile. It is water-soluble and well-tolerated at doses up to 1000mg daily in clinical research. This formula is designed for ongoing daily use to maintain optimal NAD+ levels.

This formula contains medically recognized nicotinamide riboside and resveratrol to support healthy cellular energy production, metabolic function, and antioxidant activity. Nicotinamide riboside plays a documented role in supporting NAD+ pathways that contribute to mitochondrial efficiency and daily energy needs. Resveratrol provides additional antioxidant support and assists with healthy aging and cellular resilience. This supplement may be used to support individuals experiencing nutrient depletion, increased physiological demand, or age-related changes in metabolic activity.

60-Day Money-Back Guarantee

Try it risk-free! We’re confident you’ll experience enhanced energy, improved cognitive function, better physical performance, metabolic support, and comprehensive cellular anti-aging benefits. If you’re not completely satisfied within 60 days, simply contact us for a full refund — no questions asked. Your health and satisfaction are our top priorities.

The Wellness Store Difference

At The Wellness Store, we’re committed to providing premium NAD+ supplements that deliver real results. Our NR+ 300 combines pharmaceutical-grade Nicotinamide Riboside with 98% pure trans-resveratrol, tested for purity and potency. We stand behind every product with our satisfaction guarantee because your cellular health, longevity, and overall wellness are our priorities.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use, especially if you have medical conditions, are pregnant, nursing, taking medications, or have cancer or autoimmune disorders.